Preimplantation Genetic Testing (PGT)

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What is preimplantation genetic testing (PGT)?

For couples struggling to have pregnancy due to uncertain challenges, also go through PGT to identify the hurdles in pregnancy. PGT is the test conducted to help fertility doctors to get the unique opportunity to understand if there is any genetic complication or not for the further process of fertility treatment. Simply, it is the procedure where the embryos are examined for genetic abnormalities before transferring them to the uterus during IVF treatment.

At Fertinova Fertility-IVF Center, you will find the advancements in reproductive technologies like PGT listed below to screen the embryos before implantation to have a healthy pregnancy where the baby is free from such hereditary concerns. PGT is affordable in IVF treatment and consists of three types:

1. PGT-A:: Aneuploid embryo can lead to miscarriage or implantation which is why PGT is done to screen the presence of an abnormal number of chromosomes.
2. PGT-M: PGT-M testing is done to check whether the couples have any genetic disorder and the embryo is not carrying the same.
3. PGT-SR: PGT-SR testing helps fertility specialists identify the embryo with a balanced chromosomal structure rather than having the risk of unbalanced structural abnormalities.

What is the procedure of Preimplantation Genetic Testing (PGT)?

1. Egg Retrieval: IVF fertility begins with the ovaries stimulation for multiple eggs to get matured so that they are retrieved from the ovaries.
2. Fertilizing to Form an Embryo: As the eggs get matured, they are fertilized with the sperm to create embryos.
3. Biopsy: At this stage, a tiny piece is taken from the outer layer of cells of the growing blastocyst to collect a few cells for genetic testing.
4. Genetic Testing: Once, the cells are extracted, they are sent to examine whether there are any chromosomal abnormalities with the embryo.
5. Selection of Embryo: The fertility specialist uses the genetic information derived from the PGT to identify and select healthy sperm before the transfer.
6. Embryo Transfer: As the healthiest embryo is selected and checked for its functioning, the embryo is successfully transferred into the uterus.

Who should take the preimplantation genetic testing (PGT)?

What is the success rate of the Preimplantation Genetic Testing (PGT)?

The success rates of preimplantation genetic testing differ depending upon certain factors such as PGT-A, PGT-M, PGT-SR, pregnancy rate, birth rate, miscarriage rate, and so on. With PGT-A the success rates are higher considering the age, health of the reproductive system, and the quality of the embryo. Ranging from 60% to 80%, the study shows improved live birth rates by identifying the embryos that lower the risk of birth defects in order to take uniform decisions in their pregnancy journey.

What is the success rate of preimplantation genetic testing (PGT)?

The success rates of preimplantation genetic testing differ depending upon certain factors such as PGT-A, PGT-M, PGT-SR, pregnancy rate, birth rate, miscarriage rate, and so on. With PGT-A the success rates are higher considering the age, health of the reproductive system, and the quality of the embryo. Ranging from 60% to 80%, the study shows the improved live birth rates by identifying the embryos that lower the risk of birth defects to take uniform decisions in their pregnancy journey.

What are the benefits of preimplantation genetic testing (PGT)?

1. Identity of genetic disorder: The biggest benefit of doing PGT testing is that IVF specialists identify if the embryo has the same genetic disorder through parents or not.
2. Increase IVF success rates: After the PGT, there are high chances of IVF success rates transferring the embryo into the woman’s womb.
3. Successful pregnancy: After the selection of a healthy embryo and the examination of PGT, there are many chances of successful pregnancy outcomes.
4. Family Planning: With the PGT test, you can get all the information regarding the couple's genetic information that helps them in family planning.
5. No miscarriage: The chances of unexplained miscarriage can be reduced by identifying the embryos with balanced or unbalanced chromosomal structures while transferring to achieve the pregnancy.

What are the potential risks of preimplantation genetic testing (PGT)?

While PGT offers multiple benefits it also comes with certain disadvantages,

1. Lack of guarantee: PGT helps you get insights into genetic issues if any, but a healthy pregnancy is not guaranteed with this procedure. As it is a way to increase pregnancy chances, several factors play a key role in the IVF fertility procedure to have a successful pregnancy.
2. Embryo selection: The specialist must be careful while selecting the embryo for transfer into the parent's womb. If a wrong embryo has been selected, then there are chances that the embryo can be damaged.
3. PGT Results: Some embryos have a mixture of normal and abnormal cells that can cause false positives or false negatives in results and due to some technical issue sometimes it may not give accurate results.

PGT treatment cost: PGT, which involves genetic testing of embryos, is a new technology and is not usually covered under insurance which can be expensive for the patient, yet the cost may vary from hospital to hospital. We have reasonable prices for PGT treatment, which is quite affordable.

Success Rates

Individualized treatment and specialized personal care are the two essential factors that influence our successful fertility treatments. Fertinova Fertility Centre’s approach is impeccable with Dr. Radhika Reddy’s 25 + years of extensive experience in the field of fertility, well-supported by highly qualified medical and paramedical staff, State-of-the-Art IVF Lab and emphasis on Blastocyst culture, laser hatching and single embryo transfer, has consistently made strides over the years.